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It has happened in some countries already, they owe more than they are going to make this year! Imagine if you paid every penny

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

you earned this year and it did not cover your payments! Now factor in taxes, food, housing and some entertainment and we are

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

in way over our heads. We are going to drown.

How do we rescue someone drowning in debt? The easiest is to throw them a life r

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ing and drain the pool. The life ring is some self-control and the pool is our spending choices.

Advertising is really good an

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

d getting better. The sole purpose of all radio, TV and print is to get you to buy something. Even the weather has plugs for pr

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

oducts or they show a store in the background shot. The Ad’s work on our self worth, promising if we buy it, we will get the gi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

rl, save the world and be famous. Nothing can be farther from the truth, but there is more money spent on advertising than educ

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ation, so we keep spending.

How can we get control of ourselves then? The quick way is move to a desert island, preferably wit

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

hout a big-box store on it. If you have no place to spend your money and you can refrain from gambling with the other castaways

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

you will do just fine. However most of us are not going to move to Gilligan’s Island.

Can you stop yourself from reading the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ale pages in the newspaper? We look at those pages and think, wow it’s 50% off, I can afford that. Until you build up some ment

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

al toughness do yourself the favor and don’t put yourself in temptation's way.

The longer-term answer is to gain mental toughn

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ess to withstand the lure to purchase everything in sight. You do that by consciously practicing. Pick a day and lock your wall

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

et up. Now go to the store with no money, set the alarm on your watch for 30 minutes. Walk around the store and notice all the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

things you would like, try them on and when your alarm goes off LEAVE the store at once.

Notice how you feel. Likely you will

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

be working on yourself to go get your wallet and buy that last outfit, or the new hammer. Just notice how you feel and watch t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hese feelings will pass and you will go onto the next feeling, such as, "I am hungry." You will not die from the feelings of no

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t purchasing things. Once you have learned to notice the feelings of, “I just gotta have that” you will be able to say no to yo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

urself. Wait long enough and the feeling will pass.

This is the solution to drowning in debt, you must spend less than you mak

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e. The answer is to be okay with not purchasing everything you would like to. Pick a day and start practicing, before you drown

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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