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We all want to get out of debt, it is really simple when you think about it right? All you need to do is earn your paycheck weekly, bi-weekly, or mo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nthly and spend less. Really easy when you actually stop to think about it. However, this is where the age-old saying “easier said than done” comes

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

nto play. Sure, it is easy to say we can get out of debt by spending less, but actually doing it another thing, much harder, less achievable for man

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y people.

To get out of debt you have to have a plan of action, you have to know exactly where you stand financially right here, right now. Until y

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

u know where you stand, you can not hope to adequately and efficiently become debt free. With that said, the first step to getting out of debt is ac

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

essing your current situation. Do you currently have more debt that you can handle? Too much debt? The best way to understand this is to understand

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

your debt to income ratio.

The debt to income ratio is a calculation that is used by many creditors in order to determine if you can handle your cu

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rent debt load, with any other additions as well. However, you can use it yourself to determine if you are in way over your head. Debt is how much y

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ou owe to creditors, income is how much you make each month, and ratio is the two compared to each other.

The best way to determine the health of y

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ur financial life and get out of debt is by calculating this ratio. If you have a 30% ratio, you are doing really well. Anything between 30% and 36%

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

you are ok. Anything between 36% and 40% is needing a little attention, borderline. Anything over 40% is awful and requires immediate attention. Yo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

u see between 36% and 40%, you will likely have a hard time making all your required payments, which could lead to serious debt problems.

How do yo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

work out your debt to income ratio to get out of debt? Well, get yourself a piece of paper, a pencil, and a calculator. On one side of the paper, m

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ake a column for debts, on the other side make a column for income.

Under the debt column, you will want to list the following, in regards to the p

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

yments you make each month:

Mortgage Payments (This includes insurance and property tax) – If you do not have a mortgage, list your rent payment.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

> Loan Payments
Car Payments
Credit Payments (Revolving such as appliances or furniture)
Student Loans
Credit Cards (Minimum pa

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

yment times 2)
Child Support

At the end of this column, add up all your payments for the month and place the total. In the next column, start

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

your income for the month, which includes:

Take home Income
Overtime and Bonuses received annually (divisible by 12)
Other Monthly Incom

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e

After you have listed your income, add together and place the total.

The next step is dividing your debt column by your income column; the amoun

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

is your debt to income ratio.

You will then know where you stand and what you have to do to get out of debt and start living a more debt free life

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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