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Sweden – which has been a constitutional monarchy since 1809 - is ranked as having the best creativity in Europe for business and is a talent magnet for the world’s most educated workers. The bo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ok The Flight of the Creative Class by Richard Florida includes an index to measure the kind of creativity most useful to business – talent, technology and flexibility – and found Sweden to be t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e number one spot in Europe and the world.

The top ten countries, in descending order, are: Sweden, Japan, Finland, the US, Switzerland, Denmark, Iceland, the Netherlands, Norway and Germany.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

f your image of Sweden and Denmark is still that of a socialistic, slow growth, bureaucratic economy - you need to join me as I lead a small group of individual investors to visit to both Stockh

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lm as well as Copenhagen, Denmark during the third week of June 2007.

This tour, organized by luxury travel company Abercrombie & Kent, will include visits to major companies like Ericsson and

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

olvo, the Copenhagen and Stockholm stock exchanges, briefings by me and a leading investment firm on opportunities in both countries as well as major historical and cultural sites in both countr

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

es. We will stay at two 5-star Leading Hotels of the World: the Grand Hotel in Stockholm and the D’Angleterre in Copenhagen.

The Kingdom of Sweden, with a population of 9 million and area excee

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ing that of California, has many attributes which investors should appreciate. King Carl Gustav (no relation) has reigned since 1973 over a well educated citizenry. It is blessed with ample natu

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

al resources like iron ore, copper, gold, timber, lead, zinc and hydro power but 70% of its economy is driven by services. Sweden’s per capita GDP is $30,000 and it has a balanced budget surplus

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

current account surplus, opted out of euro in 2003.

While Sweden's industry is primarily in private hands, the newly elected center-right coalition led by Mr. Fredrik Reinfeldt is moving ahead

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

with promises to privatize up to 47 companies that may collectively fetch as much as $100 billion. This, in addition to Sweden’s fiscal discipline, tradition of craftsmanship and ample natural r

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

esources, adds to the allure of this market. The strength and stability of the Swedish Krona is another big attraction. The Swedish Riksbank - the oldest central bank in the world - this week ra

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

sed its benchmark interest rate to 3.25% and is currently focusing on price stability with an inflation target of 2%.

We have had the Swedish exchange-traded fund or ETF (EWD) and from time to

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ime the Swedish Krona currency ETF (FXS) in some portfolios for some time with positive results. The Sweden ETF is up 37.6% over the last 12 months. Ericsson accounts for 21% of the basket with

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

uality companies like Svenska, Sandvik, Volvo and Atlas Copco all top ten holdings that readers might be familiar with. Capital good, technology and banking each contribute about 20% of sector e

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

posure for good balance and diversification. Plus, while the main Copenhagen and Swiss indexes are trading at 19.5 earnings, Sweden is trading at 14 times earnings. Here are some point and figu

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e charts from my partner Don Smith for EWD and FXS plus some commentary on where these ETFs might go from here.

A quick review of EWD paints a story of demand. As you can clearly see from the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

bove point & figure chart all but just a few months since the inception of this ETF have been in demand. A hundred shares of this ETF would have cost you $2,296 back on January 3, 2006. Today

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

hat investment would be worth $3,285 for a growth of 43.07%.

FXS is a new issue that seeks to track the price of the Swedish Krona, net of trust expenses. The green shade line above represents

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

he cost basis of one share at the issue date of June 6, 2006. One obvious pattern of this FXS is its volatility. There have been 17 reversals in nine short months with an overall gain of 4.28%

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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