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Food commodities are traded to international markets across continents and distributed to reach remote places also.

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

The food commodities are ranked based on availability productivity, and demands of the increasing population. Non-

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

rocessed food items such as whole grains, pulses, spices, cashews, frozen foods, fruits, vegetables, milk, eggs and

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

many more are food commodities that are traded to native or internal markets and international markets. Processed f

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

od commodities include edible oils, butter, cheese, cedars, fruit juices, sauces and all types of flours. The food

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

industry is a multi-billion dollar business and the world's largest industry.

Handling food commodities includes m

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ny important factors that cannot be ignored such as storage, shelf life and temperature conditions. Storage space r

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

quirements should be given careful attention, as the amount of space necessary in a warehouse depends upon the tota

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

volume of food stored and on the number of different commodities. Separate stacks require more usable volume than

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

one large stack; hence, each commodity should be stacked separately. Shelf life refers to the average amount of tim

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

a product may be stored without nutritional deterioration. A food commodity can deteriorate for several reasons su

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

h as aging, microbiological decay, chemical and physical degradation and texture changes. Deterioration of food com

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

odities can be reduced or slowed by careful processing, packaging, handling and storing. Universal guidelines for c

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ontrolling temperature and humidity conditions to suit the various food commodities are impossible, because these c

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

nditions and the operating environment vary from place to place. However, some basic instructions can be followed s

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ch as keeping all food commodities in dry conditions, storing wet and dry foods separately, cross-ventilation in th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

warehouse, sunroofs and covering food commodities during transportation.

Besides food commodities being a profita

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ble trading business, large quantities of food items are donated through food distribution programs as relief measu

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

es. The commodities required food programs use inexpensive food staples to provide basic nourishment to populations

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

in extreme food security emergencies, as well as for development activities designed to address food security goals

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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