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Re-completing an older oil well can make great economic sense with oil prices above $50 per barrel. As an

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

investor, two important factors that can not be avoided are cost and risk. Re-entry or reworks, as they

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

are called, when examined on a cost and risk basis can be attractive candidates for further research.

As

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

we all know too well, even with the greatest technology, dry holes do happen when you drill for oil. As a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

n accredited investor, if you can not bear the risk of a dry hole, you should not be in the oil game to be

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

gin with. If you are an accredited investor, but would like to enter the oil markets slowly, consider loo

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

king at a reentry or rework deal.

The advantage to these type of deals is that you know ahead of time wha

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

t the original owner found downhole. Careful analysis of logs can yield potential zones that were never e

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

xploited. Also, since many older wells were drilled, new technologies such as the GasGun and Radial Jet E

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

nhancement have evolved and can boost production significantly. Petroleum engineers can even make calcula

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tions as to the amount of oil potentially recoverable based on log analysis.

Drilling a new well is not a

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

cheap proposition. I recently was sent a quote from one of the largest contract drillers in the midwest

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

for a 4000 foot well. Assuming no problems, it would cost over $240,000 to drill and complete a well. Als

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

o, site prep fees can be reduced because the location is already accessible which is important in hard to

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

get to locations and the survey/plat simply needs to be updated. If costs are lower, risks can be conside

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

red lower because investors get a faster return of investment dollars.

One final advantage is time! Ther

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e is a huge waiting list for rigs to drill new wells. In the meantime, there are thousands of wells that

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

could be re-entered or reworked. As in any oil deal, make sure you do your homework. Re-works do involve

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

risk and success is not a sure thing. Before I commit to a new re-work project, I try to remember what my

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

old high school track coach always told me.......the 6 P's, PRIOR PLANNING PREVENTS PISS POOR PERFORMANCE

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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