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    The market has been slowly (well, not so slowly in my case) coming down so I called my broker to find out what to do. And I t
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    hought I was confused. He did have some suggestions such as this is a good buying opportunity so send in more money and we (
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    catch that “we”, but it’s my money) can buy some more shares and dollar cost average so when the market turns back up I will
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    make a nice profit.

    Problem is he doesn’t know when that will happen. I asked about selling my shares and waiting until “we”
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    saw it going up again and then I could buy back in. He definitely did not like that idea and told me I could not afford to b
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    e out of the market as I could miss the next big up move. He did not mention anything about missing the next big down move.

    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    He gave me that worn out story about staying in for “the long haul”. The truth of that story is it takes 30 years to wait it
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    out and I don’t have that long. If I had been a shareholder in 1929 and not sold out I would have had to sweat it 25 years to
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    get back to even. Even is not what I had in mind. Even doesn’t make any money.

    One of my friends told me to ask him about t
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    he 16-year cycle of bull and bear markets. He seemed confused at first, but as soon as he realized I didn’t know anything he
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    ecame the expert again and told me there was nothing to it. Later I looked it up and found out he was wrong and was BS-ing me
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    so I would not sell.

    Going back for more that 100 years there is a pattern of approximately 16-year bull and bear market cy
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    cles. The last bull cycle was 1982 to 2000 (OK 18 years, close enough). According to the cycle we are in the next bear phase
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    may (I did not say would) last until 2016 or thereabouts. During those long term bear periods there are shorter term bull cyc
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    les. But you have to be smart enough to be able to see when those turns occur.

    My broker who is (supposed to be) smarter tha
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    t I am said it is not possible to time the market - just buy and hold. Isn’t he supposed to know this?

    I went on the Interne
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    t and did a search about “market timing”. I was buried with all the information. There are many ways to do it so I looked for
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    the simplest one I could find as I did not want to be trading in and out and also did not want to watch to market all the ti
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    me. Was there one that I could relax and look at weekly or even monthly?

    I did see one called Two for the Money and showed i
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    t to my broker. He didn’t like it. Maybe because it involved equities that paid no commission.

    I think I’ll get a new broker


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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