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    With the UK property market cooling off and rate hikes looking certain, property investors are now look
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    ing outside the UK for their investments.

    Bulgaria is set to join the EU next year, this combined with
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    cheap resources have turned it into an attractive proposition for International property investors. Ba
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    nsko is one of the favourite locations, once a small rural community it now resembles a large building
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    site; it has even been given the nickname ‘Little England’. It all started in Bansko with the introduct
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    ion of the ski gondola in 2002, from then it has not looked back. With Bulgaria’s fortunes set to chang
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    e and property value 5 times cheaper than France, there is little wonder that property investors worldw
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    ide are now taking an interest.

    The amount of developments planned at Bansko is now viewed as excessiv
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    e, this has led to a suspension of planning permission for any future developments in the area. This an
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    d the sheer demand have over inflated the property prices in the area, currently a 1 bedroom apartment
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    is selling for approx ?50,000. Still this is viewed as cheap compared to property at other European ski
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    resorts.

    A good rental income from these properties is possible due to the cheap cost of living in Bu
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    lgaria, an example is, a pint of beer currently costs in the region of 40p. The only downside to rentin
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    g an apartment would be the competition form the other 1000’s of apartments. The amount of apartments c
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    ould also prove problematic for any investor looking to sell in the future.

    My own research has made m
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    e look away from Bansko, recently I came across a ski-golf development at the foot of the Rila Mountain
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    s, just a few miles away from the ski resort of Borovets. The development due for completion in 2008 is
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    being constructed around a Nicklaus golf course. The Private gated complex will have restricted access
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    to property owners and their tenants.

    As this development combines golf and skiing it is viewed as a
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    great potential for any property investor. There is no wonder the off-plan villas are being snapped up.


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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