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The basic difference between leasing a car and buying it is that the former pays for the period the car is used, whereas the latter pays for the entire cost of the car. Thus

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

, if you lease a car, you only have to pay for the period that you are going to use the car. After the period is over, you can turn the car in and lease another one. But whe

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

n you buy a car, you own it.

Suppose a car costs $20,000 and you lease it for two years. If the value of the car after this period, taking depreciation into account, were e

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

timated to be $12,750, then you would have to pay only the value that you have used up. This would be $11,250. This amount can be paid in monthly installments. Many province

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s add a sales tax to the monthly installments. However, in an outright purchase, you pay the entire cost of the car or take a loan to pay for it. To repay the loan, there ar

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

monthly installments calculated on the entire value of the car, which would be $20,000 according to the above example. So the installments on the loan would be significantl

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

y higher than those on a lease.

It all depends on the discretion of the buyer whether a lease or an outright purchase is more convenient. Leasing a car does not mean owning

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the car; it is more like renting a car for the particular period. A leased car is the dealer's property, and you are paying for the usage. You are required to take good care

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

of the car. Dealers charge a deposit when you lease. If your records of car maintenance are not satisfactory when you turn the car in, you stand to lose the refundable depo

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

it. Lease dealers also set a limit on the mileage of the car per year-- something like 12,000 to 15,000 miles. If you exceed this limit, then you have to pay 0.10 cents or m

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ore per excess mile. Thus, leasing does not work well for people who travel a great deal. It is understandable that an accident would terminate the lease on the car, and you

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

would be obliged to buy it and finish paying for the lease. Making the lease period coincide with the warranty period of the car so that all major repairs are covered can e

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

sily prevent this.

When you buy an automobile, you are totally responsible for it after the warranty period is over. Loan payments also include depreciation charges because

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

you are using the car. The remainder of the payment adds up to the value of the car, termed as equity. When you buy a car, you also pay a sales tax upfront, making it more

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

xpensive than the price quoted. There are also delivery charges. The advantage is you own the car.

Leasing entails some problems. For instance, the estimated depreciated va

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

lue of the car is always less than what its market price would be. Imagine a car that costs $20,000, and its estimated value after two years depreciation is $12,750. In rea

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ity, the price would be higher after two years, say about $14,250. You stand to lose the remainder or $1500, even if you trade your car in or re-lease. Also, when you lease

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

a car, it is wise to take out guaranteed auto insurance (GAP). This insurance protects you in case of theft or an accident during your lease period.

The dilemma of leasing

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r buying a car is ongoing. It actually depends on the person. People who do not wish to own a car, drive carefully, want lesser payments and have a penchant for changing car

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s every two or three years may prefer a lease. But, if you have an inclination to own your vehicle and don't mind paying a higher price, then you should purchase it outright

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Here are some points to help you analyze the pros and cons of debt consolidation loans.

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