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Buying a car is expensive; there is no getting around that. It's easy to pay as much for a new car today as one might have paid for a h

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ouse a generation ago. But they are more complicated than they used to be and they are safer, too. Still, there is the matter of the m

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ney, and if you don't have a lot to spend you may be considering leasing instead of buying. The low monthly payments offered with lease

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

can be appealing, particularly if you are on a budget.

But there is more to leasing a car than just the low payment advertised in the

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ommercial on TV. Anyone who is in the market for a new automobile should consider the pros and cons of leasing a car as opposed to buyi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

g one.

Here are some of the good points about leasing a car:

The payments are lower – Sure, the payments are lower; you are only p

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ying for the portion of the car's value that you are actually using, and not the car itself. The lower payments could help budget-minde

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

shoppers, or they could allow the consumer to make a deal on a more expensive car than he or she might have otherwise purchased.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

Less cash outlay – It's possible in many cases to lease a car with less out of pocket cash than a purchase requires. This could hel

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

some shoppers who don't have a lot of cash for a large down payment.

The drawbacks to leasing include:

Excess mileage fees

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

– The lease spells out how many miles you may drive per year; if you exceed the total over the life of the lease you will have to pay ex

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ra. That extra fee could be as much as 25 cents per mile and some leases permit as few as 10,000 miles per year. If you drive a lot an

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

you fail to consider this, you could be paying a lot of extra cash at the end of the contract.

Early termination fee – If y

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

u have to end the lease early, the fee charged could be huge. How large? You might have to pay everything owed on the remainder of the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

contract. Even if you don't plan to end the contract early, it sometimes happens in the form of auto theft or an accident.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ou don't have a car – This one seems obvious, but with a lease, you don't actually own a car. When the contract is up, you give it back

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

and you have nothing tangible to show for the money you have paid. You may, of course, purchase the vehicle for an agreed-upon price, b

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t otherwise you will find yourself, once again, without a car to drive.

For some people, the advantages of having a fairly new ca

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

all the time makes leasing a good choice. For people who drive a lot or who want to get the most car for their money, buying is probab

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

y a better options. Consider the pros and cons carefully in order to decide which method of acquiring transportation works best for you

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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