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Like many other hundreds of thousands of North Europeans, we have been smitten by the prospect of owning a second home in the sun in Spain.

We were attracted buy the almost year

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

round sun, the cheaper living and the relaxed lifestyle that we just don’t have in the UK. Many thousands of ex UK residents have sold up and moved across and changed how they liv

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e with the expectation of a better and a longer life.

Like many, we booked ourselves on an inspection trip to see what was on offer and at what price. We had already had two trip

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s across previously away from any salesmen to decide on the area, prior to the inspection trip. We had now decided we were going to buy, providing a suitable property was shown to

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

us.

This all happened over two years ago now, amiss of a hug increase of property prices and a shortage of good homes. But of course things do change and now on reflection we ca

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

n comment on things that were not discussed by the salesmen on our inspection trip and what we learnt on the way.

1/ Completion Date.

We already had an idea to ignore any comple

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

tion dates and add at least 6 months to what is quoted. However many who bought in the same complex as us had sold up at home and had no option but to rent in Spain for 7 months a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

fter the quoted date. No one informed them that it would be this late and during the build the agents claimed everything was on schedule.

2/ Extra Legal and Administration Costs.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

We were given a ballpark figure that a further 10% on top of the purchase price would be needed to cover purchase tax and other legal and administration costs. We learned soon a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

fter signing that this could be a gross understatement. Many previous buyers had received unexpected bills on their doormats for administration costs and extra visits needed to ge

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t legal papers etc. We were lucky and employed a Spanish solicitor to do all this for us and it cost only 1% of the total cost. This included signing for the house in our absence,

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

taking care of keys etc. They were excellent. Of courses we still had the 7% purchase tax to pay still.

3/ Crime Just after taking Ownership

There is a real issue with crime fr

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

om property in Spain in certain areas, but it especially high with new properties. Most who buy think about adding security grill etc as secondary importance to say furniture, rat

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

her than a necessity. However in the Torrevieja area, just about without exception every new development suffers from crime until all the residents get security grills on and more

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

people start moving in and monitoring workmen and strangers. Again, anyone selling property never mentions the cost of the grills and how important it is to ensure your home is s

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ecure before you anything of value in it. It would also be wise to get home and contents insurance too.

Often the empty houses within the complexes give access to the roofs of th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ose who live there or holiday there. It is worth noting that most of the crime on our complex has occurred whilst someone was holidaying or living there. The burglars are more int

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

erest in credit cards, passports and jewellery etc, things that you would only have if you were staying there.

Unfortunately in a few cases, some people who had intended to live

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

in Spain have returned home because of the crime and other issues. However if they had known before hand and had protected themselves from this, they may have still been in the su

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nshine. If you intend to move out there or buy a holiday home, consider buying a used home where the crime will have settled and security grills in place and no extra legal costs.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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