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Although there are several formulas that real estate investors can use when trying to determine the value of a real esta

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

te investment (cost, income and comparable sales approaches), what formula can a real estate investor use to make sure t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

hat they “make money when they buy and not just when they sell”?

Yes, things like property appreciation, making improve

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ents or renovations, etc. will boost the property’s value but what happens when you over pay for a real estate investmen

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t?---it could take several years for you to finally breakeven (when the market finally catches up).

I have developed a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ormula called the BPO or Best Possible Offer Rule to assist real estate investors in determining price offer parameters/

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

counteroffer guidelines when investing in residential real estate.

The BPO rule requires that the real estate investor

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hink and place a value to the various expenses associated with buying, holding and selling property---if the BPO rule is

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

followed to a tee, never again will a real estate investor find themselves short changed at the end of a real estate in

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

estment.

Use the following formula when attempting to calculate the best possible real estate investment offer:

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

g>BPO = CMV - BHS Fees – Profit

Acronym Definitions:

BPO =

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Best Possible Offer

CMV = Current Market Value

BHS Fees = Buying/Holding/Selling Fees

Here is a real time example to

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

allow you to see how it works---let’s assume that you have found a real estate investment with a current market value (C

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

MV) of $100,000 and that you want to gross 10% of the acquisition price (PROFIT) and account for $20,000 in various clos

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ng/lending/realtor fees in your counteroffer.

Based upon this example, your counteroffer could not exceed $70,000---

B

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

PO = 100,000 – 20,000 – 10,000 (10% of CMV)

BPO = 70,000

The exponential wealth in real estate investing is created on

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

all sides of the transaction---making money when you buy, hold and finally sell the property. By making money on the fro

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nt end, you reduce your overall risk and increase your chances to greater ROI (return on investment) & profits.

In toda

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

’s market, paying too much for a property can lead to a negative cash flow (if you are renting) or being upside down (wh

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

en your mortgage is worth more then your property)---this type of financial holocaust can be avoided, if you do the math

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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The fact that people's expectations influence reality can help dramatically in the negotiation process. Individuals tend to make decisions based on how others expect them to perform. When we know someone expects something from us, we try to satisfy her/him in order to gain respect and likeability.

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