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International real estate investors are attracted to overseas property owing to the potential that it can offer in investment returns. One of the most profitable

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

types of international real estate is off plan property. Some refer to this type of real estate as pre construction property which is bought at the planning stage

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Buying a property before a brick has been laid does have its risks so how can an investor avoid these risks?

Firstly it must be understood why builders want pro

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

perty investors to buy property at the planning stage. This is often to raise finance so that the project can actually start. They may be also testing the water t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

see how popular the project is to buyers. There will be a few that are trying to simply steal investment money by going bankrupt before a brick is laid or runni

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ng off with investors money.

The rewards can be substantial off plan property is priced to sell and allows for instant equity to be made by investors. Many prope

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ty investors will only invest in off plan property as it allows them to buy multiple units which are often discounted by the builders. Often developers will give

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

reassurances that indicate the planned selling price of each unit on completion. Some off plan property developments do not even have planning permission. Prof

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ts here can be substantial but presents even more risk. The price of land is always cheaper without planning permission. Once permission has been granted the land

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

is instantly worth more. This coupled with a building that is going up over time can make for a sound investment.

A builder that has constructed a few projects

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

before and has experience can be a good indicator that a builder will forefill his obligations. Deposits that are held in an escrow account will always make inves

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tors feel more secure. Employing an independent lawyer to conduct due diligence for you is another option. Recently launched schemes such as the International Dev

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

loper Information Pack (IDIP) can help protect those buying and selling off plan property by providing independent due diligence reports.

Questions to ask the de

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

veloper or agent

1.What guarantees do I have that the developer would not go under or this project would not go under?

2. Will my deposit be placed in an Escrow

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

account

3. Tell me about the building company, what work have they done in the past

4. Has the builder secured planning permission and local permissions for the

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

project

5. Are there any legal safeguards for foreign investors in the case of non-completion or poor construction work by the developer?

6. If I decided to se

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

l before completion of the project, would that be possible and would I be penalized in anyway?

7. How easy is it to buy and sell property in this country? 8. Wha

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t if I decide to sell my (residence/hotel suite)?

9. Are there any other fees while the project is being built and what about after completion?

10. What do you

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nticipate the rental income to be once the facility opens based on current rates at similar properties?

11. What is the payment schedule

12. What happens if the

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

building is delayed

13. What is the rental yield I can expect?

14. What are the tax and inheritance implications

15. What is the buying process in this countr

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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