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A big mistake investors can make is to have an arbitrary number at which they will not rise above, no matter what the value. Poor people base their

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

decisions mostly on what things cost; the wealthy, on how much things make. That is not to say that the price doesn't matter — of course it does.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

But it's not all that matters. For instance: the neighborhood in which I grew up in consists of houses that are now worth anywhere from $950k to $2

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

500,000k. In the early 70's, they were selling in the $30,000s. If one bought a house here for $30k or $35k back in that era and sat on it ever sin

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ce, would it really matter now, that they might have "overpaid" by a few grand? Appreciation has a way of smoothing things over. If positive cash f

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

low was being produced all that time, then real estate actually paid the owner to get rich. Nice, huh? And even if hadn't appreciated a tenth of wh

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

t it actually has, the benefits of ownership over time have LONG since paid for the property.

A big mistake investors can make is to have an arbit

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rary number at which they will not rise above, no matter what the value. Poor people base their decisions mostly on what things cost; the wealthy,

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

on how much things make. That is not to say that the price doesn't matter — of course it does. But it's not all that matters. For instance: the nei

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

hborhood in which I grew up in consists of houses that are now worth anywhere from $950k to $2,500,000k. In the early 70's, they were selling in th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

e $30,000s. If one bought a house here for $30k or $35k back in that era and sat on it ever since, would it really matter now, that they might have

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

"overpaid" by a few grand? Appreciation has a way of smoothing things over. If positive cash flow was being produced all that time, then real esta

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e actually paid the owner to get rich. Nice, huh? And even if hadn't appreciated a tenth of what it actually has, the benefits of ownership over ti

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

me have LONG since paid for the property.

Californians tend to swing from a pendulum of needing everything to be dirt cheap, and wanting propertie

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s to appreciate California-style. The challenge here is no one can know exactly what things will be worth ten, twenty, thirty years from now — and

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ost investors won't be able to keep their properties for that long anyway because they don't cashflow.

To all would-be investors sitting on the fe

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nce: decide whether you want to have a financially-free future to look forward to, and explore whether it makes sense for you to include out-of-sta

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

te real estate as part of that future. And please, do your homework! Internet search engines are your friend — use them — these days it's more conv

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nient to find information on various places than ever before in history. Take advantage of that, as well as talking to other investors about their

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

experiences in other places.

There's a lot of money out there and a lot of investors cleaning up who "got there first" — why shouldn't that be YOU

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Small businesses are the backbone of the economy and most are family owned. Despite these large numbers, the sad fact is the vast majority of family owned businesses do not survive the first generation of owners.

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