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In a recent article by the Bureau of National Affairs some staggering information was reported. In the article we learn that over 25%

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

of appraisers admitted to inflating approximately 50% of their appraisals! Approximately 55% of appraisers reported that they are pr

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

essured by realtor's or mortgage brokers to meet predetermined values (contract sales prices). According to Fannie Mae, 99.5% of appr

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

aisals meet the contract price. So there you have it. Properties are appraised everyday for amounts significantly in excess of their

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

eal values to meet pressures for sales prices and financing. This is problematic because of what it does not only to the property in

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

question, but to the market as a whole.

Consider the fact that one of the most common appraisal techniques used is the Market Value

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

approach. If a minimum of 12.5% of appraisals (25% of the appraisers inflate 50% of their values) are inflated, and those appraisals

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

re used to justify other property sales prices, then those inflated values are used to justify additional inflated values, (etc. etc.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

etc.) how long does it take before virtually all properties are using artificially inflated comparable numbers to justify sales pric

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

es.

It is no wonder that the housing market has taken a downturn. People are paying too much and a lot of them simply can’t afford w

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

at they have bought. In addition, this fact alone will have kept many many buyers out of the market unfairly. While you will not see

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

this article on the front page of any newspaper, it is a very big deal. It is fraud. I don’t know a nice way to say it.

I do not wan

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t to imply that all appraisers are derelict in their duties. However, when any appraiser accesses past sales data in order to produce

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

comparable values, and that data has been arbitrarily inflated, even the majority of appraisers who are honest and fair will produce

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

appraisal values higher than they really should be. These good appraisers are victims of the fraud just like you and I.

So what shou

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ld we do about this? Do your homework. Buy whatever you want for you to live in, but don’t buy any investment real estate because an

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

appraisal says the asking price is fair. Buy investment real estate based on its operations and the logical progression of the proper

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

y. Run the numbers! Get the education you need to understand the analysis process and compile the data necessary to do it correctly.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

With accurate numbers, you can buy right and not have to worry about what anybody else thinks a property is worth. Pay what you think

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

its worth and not a penny more. The quality of your portfolio will be based on the quality of your purchase decisions. Make ‘em good

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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As a very brief explanation to those who may be unfamiliar to the term, an arbitrage is the practice of taking advantage of a state of imbalance between two or more markets. A combination of matching deals are struck that capitalize upon the imbalance, the profit being the difference between the market prices.

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