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The political changes in East Europe have led to interesting events for investors, especially for those

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

who are in vesting in Real Estate. Romania, the last East European Country that joined to European Uni

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

n, surprised the world of investors generating a lot of opportunities, unexpected by Real Estate Invest

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

rs.

Many of such interesting events happened before the entrance in European Union, just after leaving

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the communist block, in 1989.

First major event in field of Real Estate was the selling of all

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

apartments in the property of Romanian State, to the Romanians who lived as renters in those apartments

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

It was a huge number, estimated at 2 million apartments. This fact led to the growing of the offer of

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

apartments for sale, at very low prices, beginning from 1000 $. The prices have grown from then, 100 ti

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

es.

Second major event was the returning of the properties confiscated by communist regime fro

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

there owners. It was a number of hundreds of thousands of apartments, that made the offer at sale to g

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ow, but this time the prices were beginning from 10,000 $, being 5 years later than 1-st event.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

>The last event was a solution that Romanian state tried to give in return of confiscation of factories

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

and little businesses in all sectors of economy. Even now, this is solved only partially, and is possib

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e never to be solved. In this third part, enters the properties of former Romanian King, Michael of Rom

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ania. He still lives, was welcomed back in Romania, and a big part of His properties were given back. O

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e of these properties is Royal Summer Castle, in the little village of Bran, in the region called Trans

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

lvania, a Castle over named Dracula's Castle. Now, The DRACULA's CASTLE is FOR SALE. The Roma

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ian Royal Family is definitely intending to sell the castle at a price bigger than 60Mil Euro. In the p

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ocess of selling is interfered the City Hall of the town Brasov, the region's capital. But if an invest

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

r will offer more than the City Hall is able to invest, then, the castle will be sold at the best price

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Lots of sales people can fill in a fact find form and tell customers what they need. But how many can skilfully allow the customer to turn these needs into a burning desire.

The vast majority of web sites for small businesses are basic informational sites. Many people rightly call these sites “online brochures.” Taking into account the price associated with developing a web site, that’s one expensive brochure! Web sites should be more than just an expensive brochure: they should be a solution to a problem.

The success of a trust to accomplish estate planning goals depends on how well the trust is managed. That success depends on the abilities of the person (or institution) named as the trustee. You'll want to choose this trustee very carefully, as he or she must weat many hats.

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