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If we observe carefully the parasitic insects and other microscopic beetles in nature, we realised that all borrow food from bigger creatures for their nourishment and growth. Fleas, lice, mo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

squitoes, ticks, leeches and others, suck blood where and whenever it is given occasion. The same phenomenon continues also in the plant kingdom. Creepers like Convolvulus, Ivy, beans, tomat

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

and lots of others, need external support for their growth and survival. In book shops and libraries we observe humans doing sιmiler things. All search patiently among old and new pag

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s to abstract new ideas for their intellectual growth. Every free intellect becomes a torch bearer in the stride for spiritual freedom. We all borrow something from somewhere to re-synthesiz

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

it afterwards to our likeness. Like the honey bee that sucks pure flower water and synthesises it into sweetest nectar in the hive later.

“This is our supreme aim, said the writer Kazantzak

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

is, to shoulder our ancestor’s heritage renewable and better forwards forever”. It is not enough to reproduce our race forward like in the lower animals, but also to uplift it intellectually

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nd spiritually upwards. “He who borrows from a similar thinker, said Burke, he doubles his own and he who borrows from his superior, rise intellectually to level with his lender”. Knowledge

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

is free for every one, only it requires a wakened perception and a ceaseless yearning to be harvested. Nothing is completely new; but they are rekindled coals from the forgotten past. Every

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ew idea is a renewable old copy of continuation. Like the primitive wooden plough that developed slowly into mechanical tractor today. All of us carry some ancestral idea and it is our sacre

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

d duty to pass it updated to future generations.

When we read Plato, we discover the thoughts of previous philosophers, Heraclitos, Pythagoras, Anaxagoras and Socrates, much riper for better

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

digestion. When we read the Christian bible, we see the platonic theory reformatted into religious dogma. When we read thinkers like Rabelais and Montainge, we discover the charming thoughts

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

of the biographer Plutarch. The strong borrow bravely and dress it with their personal colour for future storage. Progress, means, to re-synthesize the past with the present and to forward it

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

bettered for the future generations that follow. Every judicious thinker carries with him a private library, and when we read his chiselled thoughts, we ask our selves with admiration! I wo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nder which worthy books ripened his mental cells so profoundly! Like when we look at the temple Parthenon and wish to meet its architects Kallikratis, Ictinos and Phidias.

“Libra thesaurus a

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ima” said the Romans, “books are treasures of the soul”. Without books today, mankind would be undeveloped almost in a primitive state. Books are the mental archives for every human to learn

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

nd add something new of his own. If Heaven has no books at all, not every thinker wishes happily to inhabit there. What business has the bee in the deadly dessert? When the sterile sand doe

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

n’t offer a drop of flower-water to convert into delicious honey?

Reading, offers mental wealth, -writing, literal precision and speech expressive readiness. We read to learn, we write to

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

precise and we talk to express. We are valuated how we think; we appreciated what we offer and loved how we speak. When we open our mouth we reveal at same time our intellectual level. On

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e a senseless flatterer talking to Aristotle, stopped suddenly when he observed the apathy into philosopher’s face, sorry master, he said, it seems that my long speech has tired you a little,

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

By no means, answered Aristotle, I wasn’t listening to your speech.

Isn’t our mental ripeness a dignified virtue and best intellectual nourishment to better humanity? Hermanus-western cape

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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