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The biggest deception on demand publishers present is that your book will be “made available at over 25,000 bookstores worldwide.” They give writers, who are unfamilia

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

r with the industry, a false sense of success. Everyone wants their books inside Borders or Barnes and Noble…but it’s just not possible. Let me explain why.

Print-On-

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Demand (or Publish-On-Demand) books are printed as little as 1 book at a time. This means their unit price to print and buy is higher per book. Example. My novel, In T

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

he Blood, spans over 330 pages. Because of its length the unit price per book is around $7. Incidentally, the longer the book, the more you pay for each unit; the shor

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ter the book, the less you pay. Following me so far?

That’s just the publishing. Now, there is a shipping fee for each unit…actually, there is a double charge on ever

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

shipping for each unit (printed book). When all the necessary fees are applied, the total cost to print and ship one book to anyone is about $13. A pretty shocking re

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

velation considering that the retail price of the book is set at $14.97, which is the thriller markets cap for a softbound book. Anything over that would price the boo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

k out of the market.

Bookstores want a 55% discount off the retail price, sometimes 65%. Let’s say they want 55. The book costs about $15. That’s an $8.25 discount wh

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ich means that the bookstore wants to purchase it for $6.75 per book. Well, it costs the publisher $13 so they would be losing $7.25 plus profits every time bookstore

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

owners placed an order. On top of that, for some strange reason, Borders and Barnes and Noble thinks they’re in the business to make money. So they want profits on top

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of the $6.75.

Typically, bookstores want to make about a 5 to 1 ratio on all book sales. That means, if your book costs $1 to purchase from the publisher, they want $

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

5 for each book. If it costs $2 to purchase, they want $10. Whatever leftover is divided between the publisher, the agent (if you have one) and the author…the author g

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

etting significantly less. Makes you nauseous, doesn’t it?

A book that is printed at $13 doesn’t stand a chance, seeing that there is NO way for the anyone to profit.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

If the bookstore purchased the book, even in bulk, they would be losing more money than they’ve earned. So where’s all this talk about being “made available at over 2

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

5,000 bookstores worldwide” coming from? Dishonest publishers who know the market, know it’s not possible, but also know that YOU don’t know either of these! So sad.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

hat that statement simply means is that your book will be placed in the catalogue that all bookstores purchase from (The Ingram Book Group, for example), making them “

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

available” for order. But no bookstore in their right mind will make the gamble, even if the book has bestselling potential. Now, you have a few success stories but th

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ey are a vast minority.

The purpose of me exposing this myth isn’t to discourage self publishing, but to encourage you to approach it with realistic expectations. Use

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the self published book to gain attention from targeted audiences (the scope of that topic is another article). If you are already self published, you’ll do much bett

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

er doing direct sales to customers than to try and get shelf space. If your book is any good, it will sell. You just have to be imaginative and sell outside of the box

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Some pros and cons to satin paper. Quality. Quick drying. 16 million colors. Compared to other papers and thicknesses.

Leadership is a state of mind. Who are the true leaders? Do you need to be a leader in order to succeed in the network marketing business? What does it take to be a leader?

Why Plan Your Estate? The knowledge that we will eventually die is one of the things that seem to distinguish humans from other living beings. At the same time, no one likes to dwell on the prospect of his or her own death. But if you postpone planning for your passing until it is too late, you run the risk that your intended beneficiaries – those you love the most – may not receive what you would want them to receive either because of extra administration costs, unnecessary taxes or squabbling among your heirs.

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