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This is something that anyone with an email address these days, may hear or say quite often. Why? Well because of the relatively unreliable nature of email delivery systems.

Here is a comprehensive list of what your email message goes through in order to get delivered:

* Virus Checks - The majority of virus (an

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

d worms) these days, travel around the internet by way of email messages. In order to protect valuable network systems from being attacked by a virus, most corporate networks and Internet Service Providers employ virus scanners that look for viruses and worms in much the same way that anti virus scans on your des

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

top computer. Most email server are set up to delete or quarantine any message that tests positive for a virus.

* SPAM filters and the huge growth of SPAM - Everyone hates SPAM! So much so, that people will change their ISP providers or email host to get better protection from SPAM. As a result, companies like A

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

L and MSN spend tons of money coming up with new ways to provide "better" spam protection to their subscribers to reduce their attrition rates.

* SPAM filtering methods:

Phrase filters - watch what you say! Many email servers use a list of unacceptable, or offensive word and phrase lists and will reje

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t or place the message in a junk folder upon a match, so watch what you say, or your message could be rejected.

Connection Checks - poorly configured email servers can cause loss of messages. This is most likely out of your control (unless you are a server admin), but just be aware that when email servers ta

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

lk to each other, some are very picky about allowing a connection and may reject it if the source server does not "check out" properly.

Statistical Analysis - this is used to catch some of the techniques used by spammers like many repeated words or a bunch of unrelated words stuffed in the message (usually t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

try to throw off the spam filters). Your message can become a victim of this if you do something like copy and paste a data file into the body of your message or if you were to insert a data file (like a mail list or spread sheet) into your message, as opposed to attaching the file.

Domain Black Lists - You

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ISP does not like your friend's ISP! - server administrators will use a list of trusted (and sometimes not-so-trusted) domain and/or IP address lists to filter incoming messages. If you happen to be using one of the "bad" service providers, your messages could be dropped. Watch the company you keep!

HTML co

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e checking and filtering - Don't get too fancy with your Html email messages. Many servers are set up to reject messages that contain certain html code. Especially scripts, deceptive URLs or encoded text.

Discretionary Blocking by email address, domain, or IP block. - Most email server give the admin the pow

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

er to place a block in their server to deny access to any server or domain of their choosing.

Server Rule Sets - in addition to all of the above obstacles, most email servers can be custom configured with rules that will redirect or delete messages on just about any content that you can think of! A incorrect

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

y coded rule could create a virtual sink hole for messages. Now, assuming your message gets through all of the above checks, the next pitfall is in the email client program, like Outlook.

* Email Client Rules and Filters - Just like servers can have rule sets that redirect or delete messages, most email

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

client software also has the ability to create custom rules to delete or move messages into a folder. Again, an improperly coded rule could create a black hole for your message.

* Unsolicited Message Filters, or Junk Filters - Most email client software also provides some sort of Junk mail filter, like Outlooks

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

unk E-Mail filter and add-on filters like SpamAssassin. These filters have become quite reliable, but there is still a small percentage of False Positives that will occur. Your message could fall victim to one of those false positives.

Other pitfalls:

* Standards not adhered to - Although there are sets of stan

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

dards (RFCs) that software providers and administrators of server are supposed to abide to, the standards are many times loosely adhered to. In fact most email server software gives the admin the option to turn on or off specific RFC features at their will or desire.

* False Positives - virus and spam filters. -

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Every content filtering technology has a certain percentage of False Positives that are considered acceptable.

* Proprietary Systems - There are many home grown systems out there that are simply poorly written and do not conform to standards.

* The Wild Wild West... everyone configures their systems based on th

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ir view, morals and opinions.

* Quotas - Sorry, that mailbox is full - Many service providers will limit the size of your inbox. The reasons for this are obvious... storage costs money.

* Daily Delivery... no so much! - Just because your message got through today, does not mean it will make it tomorrow. Content

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

and virus filters are often updated daily. Also, the little geek behind the server administrators console may decide to add an additional filter or click on a new feature just to try it out (I know, I've done it)... again, it's the Wild Wild West.

So, how can I Fix this? What can I do?

* Mostly, be aware of thi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s.

* Request a "Delivery Receipt". Most email clients support this, however, most email clients also provide the option to ignore them when received. Still, it does not hurt to ask!

* Request a confirmation. Ask the recipient of the message to reply back to you with confirmation that they received it. This is p

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

obably the most reliable method of making sure the message was received.

* Assume Nothing - never simply assume that the message was received. You know what assuming does... It makes an ass out of you and me!

* Follow up. If the message is critical, follow up with a phone call, or with an additional email reque

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ting a confirmation.

The Result and my recommendation:

Email is a great and very convenient for daily communications, but just be aware of the pitfalls and do not over rely on email for critical communications. And please... Don't send your critical business files via email. FTP or burn on CD and send overnight

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Do you feel hype is the only way to success in network marketing? You aren't alone, but it doesn't have to be that way.

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