SIM Cards hold programming information for the GSM network along with all personal settings and data.

Palm Desktop Software

• The software included with the Treo installs the drivers that enables synchronization with Palm

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

Desktop software or Microsoft Outlook for Windows or the Microsoft Outlook Exchange server via Goodlink Service

Goodlink gives you

• Full Outlook like functionality

• Secure Over The Air Management

• E

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

panded handheld security with Goodlink Compliance Manager

• Available in English, French, Italian, German and Spanish

• World-wide coverage with Global Connect

Adjusting the Screen Contrast

• Depending

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

n the lighting conditions where the Treo is being used, the screen contrast and brightness may need to be adjusted

Press Applications Launcher

• Choose the pick list in the upper-right corner, select All

• Choose the Pr

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

efrences icon

• Choose the pick list in the upper-right corner, select Display

• Choose the brightness slider, and use Left and Right to adjust brightness

• Choose the contrast slider, and use Left and Right to

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

adjust contrast

If the Screen Appears Blank and/or Locked up

• Look closely at the screen

• If there is a dim image, try adjusting the screen contrast and brightness

• If that doesn’t work, perform a so

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

t reset

• If that doesn’t work, connect the Treo to the AC charger and perform a soft reset again

• If that doesn’t work, perform a hard reset

Performing a Soft Reset

• A soft reset is similar to restar

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ting a computer

• If the Treo is not responding or having trouble synchronizing with the computer, a soft reset may help

• Unless the battery is extremely low, a soft reset should not affect data

• Unscrew the

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

tylus tip to access the reset tool

• Use the reset tool to gently press the reset button on the back of the Treo

System Reset

• A system reset, also called a safe or warm reset, tells the Treo to stop what it’s doing an

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

start over again without loading any system extras

• If the Treo loops or freezes during a soft reset, a system reset may help

• Performing a system reset allows getting out of an endless loop in order to uninstall a third-par

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

y application causing the looping

• Unless the battery is extremely low, a system reset should not affect data

• If performing a system reset and disable conflicting applications is needed, always end the process with a soft re

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

set

• This returns the Treo to normal operation

Performing a System, Warm, or Safe Reset

• To perform the System Reset (AKA Warm Reset, or Safe Reset)

• Unscrew the stylus tip to access the reset tool
  dd to the challenges in developing combination products:
  
  Which markets to tap where the combination products can do fairly well?
  Which combination prod
  i>

• While holding Up , use the reset tool to gently press the reset button on the back of the Treo

• When the Palm Powered logo appears, release Up

• Perform a soft reset

• Some features, such as W

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

reless Mode, are not available until this step is completed

Performing a Hard Reset

• A hard reset erases all data and third party software on the Treo

• Never perform a hard reset without first trying a soft and system

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

reset

• Previously synchronized data can be restored with the next HotSync operation

• A hard reset can show if a problem stems from the Treo or an application installed on it

Hard Reset Steps

• Unscre

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

the stylus tip to access the reset tool

• While holding the Wireless Mode button, use the reset tool to gently press the reset button on the back of the Treo

• When the Palm Powered logo appears, release the Wireless Mode butt

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

n

• When the warning appears, press Up to confirm the hard reset

Turning Wireless Mode ON

• Wireless Mode connects the Treo to the service provider network so that phone calls can be made and received, and use other wir

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

eless services can be completed

• Press and hold the Wireless Mode button to turn on Wireless Mode

• At this point, Wireless Mode is on and the user is ready to begin making and receiving calls and using the Internet features (

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

f supported by the local network)

Turning Wireless Mode OFF

• When Wireless Mode is off, the Treo is not connected to the service provider network

• Other Palm OS features can still be used

• This is id

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

al for airplane flights and for maximizing battery life

• Press and hold the Wireless Mode button again to turn off Wireless Mode

• There will be a series of descending tones and a Goodbye message appears on the screen

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products