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The Chinese Government is rumored to distribute laptops to all its citizens in an attempt to nip over-population in the bud (or rather, seed). Ok, per

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

haps socialism hasn't come along this far, but recent studies do indicate that laptop use may hurt sperm production in young adult males permanently. <

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

br>
What You Say?

It's true, "teenage boys and young men may consider limiting their use of laptop computers on their laps," quipp

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ed Yefim Sheynkin, the lead researcher of an interesting (though somewhat sparse, yuk yuk) study on the effects laptops have on scrotal temperatures an

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

d sperm counts. When a laptop is balanced on one's knees, the user is forced to close their legs together, raising scrotal temperatures by an average

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

of 2.1 degrees celsius (3.8 F). Internal laptop temperatures can soar to 70 degrees celsius (158 F). The result is higher scrotal temperatures in mal

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

es by around 2.7 degrees celsius (4.86 F), according to Sheynkin's study on 29 brave male volunteers.

Someone Set Up Us the Bomb
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easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

br> Are you thinking what I'm thinking, that the US government (the same monster that somehow puts poisons in plane jetstreams to kill off the elderly

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

) was behind the advent of the laptop computer in order to control population? If so, your medication might be just a placebo. Whatever the case, st

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

udies show that 1 degree celsius is the minimal difference for inhibited spermatogenisis (sperm production). Although damage is temporary in most case

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

s, habitual and prolonged laptop use might cause permanent damage. Sheynkin said: "The body needs to maintain a proper testicular temperature for

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

normal sperm production and development. We don't know the exact frequency and time of heat exposure capable of producing reversible or irreversible

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

changes in spermatogenesis."

You Have No Chance to Survive, Make Your Time

Ok, so as inconclusive as this study seems, it is

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

an established truth that heat is bad for the little guys. Not only this, but laptops are just plain uncomfortable. There is a solution out there

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

. I have come accross the Xpad Heatshield, a handy new item that shields your lap from uncomfortable laptop heat and channels heat away quick

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ly. Perhaps the most energy consuming device in a laptop is the cooling fan. I have found that when I use my Xpad with my powerbook, the battery

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

life increases, probably by about 20% or so. Plus, I have heard that putting your laptop on a soft surface (like a pillow) inhibits heat dissipation

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

, damaging your laptop's battery permanently. Xpad protects our batteries, our posterity, and passively protests the government's evil conspiracie

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s.

The Xpad is simple in design. It is a solid base with raised rubber pads (in the shape of an "X) that raise the laptop by a little less tha

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

n an inch. It allows heat to escape quite easily while gripping your laptop firmly to the base. A pad on the bottom makes it comfortable for your lap

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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