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First of all, unlike earlier satellite communications which relied on a motorized dish to chase the mobile satellites across the sky, modern sate

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

llites are placed into a geosynchronous orbit about 37,000 km (22,300 miles) up. This means that they always remain above the same point on the e

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

rth's surface. That way, all dishes on the earth can be pointed at a fixed location, and the satellite will always be there.

The signal to be br

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

oadcast originates at an "uplink center", which collects nationwide programming from cable television networks and local programming from broadca

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t networks and encrypts it so that the programming cannot be intercepted by non-paying users. The uplink facility uses a huge dish, 9 to 12 meter

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

(or 30 to 40 feet) wide, to accurately send a high-strength signal to the orbiting satellite.

The satellite, in turn, converts the signal to a

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

different microwave frequency band, so that the downlink doesn't cause interference with the uplink. The two most common frequencies used in Unit

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

d States satellite tv broadcasts are the "C-band" (4 to 6 GHz) and the "Ku band" (12 to 18 GHz).

After traveling more than 50,000 miles, and bei

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

g converted in between, the signal that arrives at the receiving dish on the outside of the consumer's home is fairly weak. It is focused by a bo

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

wl-shaped parabolic dish onto a device in the center called a "feed horn", which channels the signal to a "low-noise block downconverter" (LNB) w

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ich filters out unwanted interference, and sometimes converts it to yet another frequency before amplifying it and sending it to the satellite re

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

eiver box inside the house through a coaxial cable.

The satellite receiver box converts the signal to an analog television, audio or data signal

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

. The receiver may be equipped to decrypt the coded signal itself, or it may require a separate box or a "smart card" plug-in (either to the rece

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ver box or to the television to perform the decoding. A single receiver can serve only one television or computer; multiple receivers must be pur

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hased to provide signal to multiple devices, including watching one channel and recording on another.

Many receivers also include integrated dig

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ital video recorders (DVR), allowing them to rewind and pause live television, and to record and store their favorite shows on a built-in hard dr

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ve. There are also increasing numbers of high-definition television (HDTV) satellite receivers and DVRs available.

Newer technologies being inte

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rated into the system include pay-per-view functionality, interactive television channels, and video-on-demand (VOD) channels.

The competition f

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

or between satellite tv providers, and between satellite and cable providers, is quite fierce. The advantages of being the first to provide new f

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

atures are driving the pace of invention among satellite technology providers, so we can expect to see many more breakthroughs in the near future

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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