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    In the last 5,000 years there are a total of 64 generations of patriarchs in three different periods known as the Green, Red and White periods. The first 18 generations of patriarchs
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    was from China, then the next 28 generations of patriarchs from India and the last 18 generations of patriarchs again from China making it a total of 64 generations of patriarchs. T
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    e patriarchs were firstly 13 generations of holy emperors started off by Emperor Fu Shi, then 5 generations of scholars with Lao Tze (the founder of Taoism) as the first scholar, fol
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    owed by 28 generations of Indian Buddhist monks in India, 5 generations of Chinese monks in China and lastly lay people from China. This is a mystical revelation by Heaven to inform
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    s the lineage of Tao that had to be prepared over a period of 5,000 years before the coming of the Final Catastrophe that will end the world.

    The Green Period - The Buddha in charge
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    of this period is Dipankara Buddha and it started around 3100 BC to 1214 BC and lasted for about 1,886 years. This period has 11 patriarchs from the first patriarch Emperor Fu Shi. T
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    is period is symbolized by the Green Lotus Leaf.

    The Red Period - The Buddha in charge of this period is Sakyamuni Buddha and started around 1190 BC to 1924 AD and lasted for about
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    ,114 years. This period has 51 generations of patriarchs from patriarch Giang Tai Gong (12th) to patriarch Liu Hwapu (62nd). This period is symbolized by the Red Lotus Flower.

    The W
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    ite Period - The Buddha in charge of this period is Maitreya Buddha and it started around 1883 AD and will last for 10,800 years until 12683 AD. This period has only two generations
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    f patriarchs, Lutsu Chung Yi (63rd), the reincarnation of Maitreya Buddha and Dignitary Master Chang Tienzen and Sun Shuzen (both 64th). The two 64th patriarchs are the reincarnation
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    of JiGong and Bodhisattva Yueh Hui respectively. This period is symbolized by the White Lotus Root.

    The Lineage of Tao told by JiGong is as follows:

    The early 18 generations of pat
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    riarchs from China are 1]Emperor Fu Shi 2]Emperor Sunlung 3]Emperor Huang 4]Emperor Souhou 5]Emperor Tsuanshi 6]Emperor Ku 7]Emperor Yow 8]Emperor Shun 9]Emperor Yu 10]Emperor Yeeyin
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    11]King Tong 12]Giang Tai Gong 13]King Wen, King Wu & Chou Kung 14]Lao Tze 15]Confucius 16]Yienwhie & Tsentzu 17]Tsuseu and 18]Mencius.

    The 28 generations of patriarchs from India a
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    e 1]Arya Mahakasyapa 2]Arya Ananda 3]Arya Sanakavasa 4]Arya Upagupta 5]Arya Dhritaka 6]Arya Michaka 7]Arya Vasumitra 8]Arya Buddhanandi 9]Arya Buddhamitra 10]Arya Parsva 11]Arya Puny
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    yasas 12]Bodhisattva Asvaghosa 13]Arya Kapimala 14]Bodhisattva Nagarijuna 15]Kanadeva 16]Arya Rahulata 17]Arya Sanghanandi 18]Arya Gayasata 19]Arya Kumarata 20]Arya Jayata 21]Arya Va
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ubandhu 22]Arya Manorhita 23]Arya Haklenayasas 24]Arya Simha 25]Arya Basiasita 26]Arya Punyamitra 27]Arya Prajnatara and 28]Arya Bodhidharma.

    The late 18 generations from China are:
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    1]Bodhidharma 2]Huik'u 3]Seng Tsan 4]Tao Hsin 5]Hung Yen 6]Hui Neng 7]Bei Yuzen & Ma Duanyang 8]Luo Weichuan 9]Huang Tehhui 10]Wu Tzusiang 11]Ho Liaokoo 12]Yuan Tuian 13]Hsie Huanwu
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    Yang Huanshu 14]Yow Hotien 15]Wong Gioyi 16]Liu Nwapu 17]Lutzu Chung Yi and 18]Dignitary Master Chang Tienzen & Sun Shuzen.

    This is beyond the knowledge of man and religion, only H
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    aven can make known to us. In the temple of Tao of Heaven, this lineage of Tao known as the Golden Thread was very nicely drawn up with details in the form of a chart. It is to pave
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    he way for human to gain enlightenment over 5,000 years by Heaven and ultimately salvation. The 64 patriarchs are the spiritual masters of devotees of Tao of Heaven.

    Author: T.A Che


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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